7P An optimized Breast Cancer Index node-positive (BCIN+) prognostic model for late distant recurrence in patients with hormone receptor-positive (HR+) node-positive breast cancer
نویسندگان
چکیده
منابع مشابه
Predictive and Prognostic Value of the 21-Gene Recurrence Score in Hormone Receptor–positive, Node-positive Breast Cancer
The addition of adjuvant chemotherapy to hormonal therapy is recommended for patients with estrogen receptor-positive (ER+), node-positive (N+) early breast cancer (EBC). Some of these patients, however, are not likely to benefit from treatment and may, therefore, be overtreated while also incurring unnecessary treatment-related adverse events and health care costs. The 21-gene Recurrence Score...
متن کاملBreast cancer index identifies early-stage estrogen receptor-positive breast cancer patients at risk for early- and late-distant recurrence.
PURPOSE Residual risk of relapse remains a substantial concern for patients with hormone receptor-positive breast cancer, with approximately half of all disease recurrences occurring after five years of adjuvant antiestrogen therapy. EXPERIMENTAL DESIGN The objective of this study was to examine the prognostic performance of an optimized model of Breast Cancer Index (BCI), an algorithmic gene...
متن کاملAdjuvant docetaxel for node-positive breast cancer.
BACKGROUND We compared docetaxel plus doxorubicin and cyclophosphamide (TAC) with fluorouracil plus doxorubicin and cyclophosphamide (FAC) as adjuvant chemotherapy for operable node-positive breast cancer. METHODS We randomly assigned 1491 women with axillary node-positive breast cancer to six cycles of treatment with either TAC or FAC as adjuvant chemotherapy after surgery. The primary end p...
متن کاملSurvival after Node-positive Breast Cancer
The goal of screening for breast cancer is to identify cancers when they are at a curable stage. The prospect for cure depends in turn on the extent to which the cancer has spread at diagnosis. If a breast cancer is entirely contained within the breast (that is, if no subclinical metastases have occurred), then complete excision through mastectomy or breastconserving surgery is expected to be c...
متن کاملFactors Predicting Late Recurrence for Estrogen Receptor–Positive Breast Cancer
BACKGROUND Adjuvant endocrine therapy beyond 5 years reduces recurrence in patients with estrogen receptor-positive breast cancer. We have previously shown that immunohistochemical markers (IHC4) and two gene expression profile tests (recurrence score [RS] and PAM50 risk of recurrence [ROR]) are associated with time to distant recurrence, and we have now assessed the value of each of these scor...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2021
ISSN: 0923-7534
DOI: 10.1016/j.annonc.2021.03.021